Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: pitfalls and intricacies from a pilot case-control study

Katleen  de Gaetano Donati; Simona Costanzo; Lara  Campana; Marco Olivieri; Rosaria  Santangelo; Maurizio  Sanguinetti; Roberto  Cauda; Licia  Iacoviello

doi:10.2427/9157

Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: pitfalls and intricacies from a pilot case-control study

Authors

Katleen de Gaetano Donati Catholic University, Rome
Simona Costanzo IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli (IS)
Lara Campana Catholic University, Rome
Marco Olivieri PICOMED Research srl, CAMPOBASSO
Rosaria Santangelo Catholic University, Rome
Maurizio Sanguinetti Catholic University, Rome
Roberto Cauda Catholic University, Rome
Licia Iacoviello RCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli (IS)

DOI:

https://doi.org/10.2427/9157

Abstract

Objectives: Influenza vaccination protects high-risk populations from severe outcomes. We assessed the feasibility of testing influenza vaccine effectiveness against hospitalization with laboratory-confirmed influenza.

Methods: All hospitalized patients with influenza-like illness within 14 days, were swabbed. Cases were positive at RT-PCR for influenza A/B.

Results: AtRome “GemelliHospital” (Season 2011-2012) 104 patients were contacted and 62 recruited. Considering total sample and target group (n= 47, 76%), only 29% and 38% had been vaccinated. Eighteen patients were laboratory-conﬁrmed for influenza.

Conclusions: RecruitedILI patients and prevalence of vaccinated subjects were less than expected. Larger numbers are warranted to study vaccine effectiveness against severe influenza outcomes.

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Published

2022-06-13

How to Cite

de Gaetano Donati K, Costanzo S, Campana L, Olivieri M, Santangelo R, Sanguinetti M, et al. Assessment of seasonal influenza vaccine effectiveness in patients from a central Italy reference hospital: pitfalls and intricacies from a pilot case-control study. ebph [Internet]. 2014 [cited 2026 Feb. 7];11(3). Available from: https://riviste.unimi.it/index.php/ebph/article/view/17987