All-cause and Cause-Specific Excess Deaths during the COVID-19 Pandemic

Authors

DOI:

https://doi.org/10.54103/2282-0930/27958

Keywords:

COVID-19, SARS-CoV-2, pandemic, Excess mortality, causes of death, diabetes

Abstract

We estimated the excess mortality during the COVID-19 pandemic (2020-2023) in selected countries worldwide. In Europe, half a million excess deaths occurred annually in the first three years of the pandemic, while a 2.1% excess was observed in 2023 (108,629 deaths). Significant excess mortality was recorded worldwide for all-cause mortality, cardiovascular disease, and diabetes, with peaks in COVID-19 cases closely aligning with these excess deaths. No increase in cancer-related mortality was observed. Gross domestic product per capita, national health expenditure, and vaccination rates were inversely associated with excess mortality. These findings provide insights into the public health impact of COVID-19 and inform future policy decisions.

Downloads

Download data is not yet available.

Author Biographies

Margherita Pizzato, University of Milan

Department of Clinical Sciences and Community Health

Claudia Santucci

Department of Clinical Sciences and Community Health

Carlo La Vecchia, University of Milan

Department of Clinical Sciences and Community Health

Gianfranco Alicandro, University of Milan

Department of Pathophysiology and Transplantation

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Mother and Child Department, Cystic Fibrosis Centre

References

Islam N, Shkolnikov VM, Acosta RJ, Klimkin I, Kawachi I, Irizarry RA, et al. Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries. BMJ. 2021 May 19;373:n1137. DOI: https://doi.org/10.1136/bmj.n1137

Msemburi W, Karlinsky A, Knutson V, Aleshin-Guendel S, Chatterji S, Wakefield J. The WHO estimates of excess mortality associated with the COVID-19 pandemic. Nature. 2023 Jan;613(7942):130–7. DOI: https://doi.org/10.1038/s41586-022-05522-2

Pizzato M, Gerli AG, La Vecchia C, Alicandro G. Impact of COVID-19 on total excess mortality and geographic disparities in Europe, 2020-2023: a spatio-temporal analysis. Lancet Reg Health Eur. 2024 Sep;44:100996. DOI: https://doi.org/10.1016/j.lanepe.2024.100996

Alicandro G, La Vecchia C, Islam N, Pizzato M. A comprehensive analysis of all-cause and cause-specific excess deaths in 30 countries during 2020. Eur J Epidemiol. 2023 Nov 1;38(11):1153–64. DOI: https://doi.org/10.1007/s10654-023-01044-x

Pizzato M, Santucci C, Islam N, La Vecchia C, Alicandro G. Relationship between COVID-19 cases and monthly mortality from all causes, cancer, cardiovascular diseases and diabetes in 16 countries, 2020–21. International Journal of Epidemiology. 2025 Feb 1;54(1):dyaf006. DOI: https://doi.org/10.1093/ije/dyaf006

Downloads

Published

2025-05-08

How to Cite

1.
Pizzato M, Santucci C, La Vecchia C, Alicandro G. All-cause and Cause-Specific Excess Deaths during the COVID-19 Pandemic. ebph [Internet]. 2025 [cited 2026 Feb. 4];20(1). Available from: https://riviste.unimi.it/index.php/ebph/article/view/27958

Issue

Section

Commentary

Funding data

  • NextGenerationEU
    Grant numbers PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project no. PE00000007, INF-ACT)
  • Ministero dell’Istruzione, dell’Università e della Ricerca
    Grant numbers The Department of Pathophysiology and Trasplantation, University of Milan, is funded by the Italian Ministry of Education and Research (MIUR): Dipartimenti di Eccellenza Program 2023 to 2027