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It's a pleasure to introduce the first issue of AMSUM (Archives of Medicine and Surgery University of Milan), which starts with an editorial and 4 high quality articles. The first one reports the results of a new surgical technique for the treatment of Bone Edema in the knee, subcondroplasty. The second one is an interesting review of an innovative and promising surgical technique for the implant of total knee replacement, the kinematic alignment. The third is a narrative review focused on diagnosis and treatment of 2 case reports of the rare 4 limbs hexadactyly in newborns. The last manuscript shows the relevant experience of the authors in the reconstruction of the lateral compartment of the ankle with allograft tendons.