Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand

Authors

  • Tum Boonrod Kasetsart University, Bangkok, Thailand Thailand https://orcid.org/0000-0002-8928-6804
  • Lily Ingsrisawang Kasetsart University, Bangkok, Thailand Thailand https://orcid.org/0000-0003-0571-091X
  • Petchawan Pungrassami Ministry of Public Health, Thailand Thailand
  • Supattra Sengsong The office of prevention and control disease region 11, Thailand Thailand
  • Arisa Bromnavej The office of prevention and control disease region 11, Thailand
  • Pinkamon Waseewiwat The office of prevention and control disease region 11, Thailand
  • Natthapakam Sreevijit The office of prevention and control disease region 11, Thailand
  • Bunrit Bunsanong The office of prevention and control disease region 11, Thailand
  • Chusri Bunsin The office of prevention and control disease region 11, Thailand

DOI:

https://doi.org/10.2427/13124

Abstract

Background: this study aimed to assess the drug resistant pattern of Mycobacterium tuberculosis complex (MTBC) and the risk factors associated to multidrug-resistant tuberculosis cases (MDR-TB) in upper part of southern Thailand. 

Methods: a total of 3238 TB cases was retrieved from a database of the office of prevention and control disease region 11. Only 1008 cases were confirmed by culture growth for Mycobacterium tuberculosis and drug-susceptibility testing (DST) during a period of 4 years (January 2013 to December 2016). The risk factors, including gender, age group, residence place, and history of treatment were analysed using multivariate logistic regression to predict the MDR-TB cases. 

Results: among 1008 TB cases included in study, 77.4% of them were males, 31.5% lived in rural area with median age of 45.0 years (IQR = 23.0), 27.6% were retreatment for tuberculosis, 25.9%, 10.8%, 3.0%, 10.7% and 9.1 were determined to be resistant to isoniazid, rifampicin, ethambutol, streptomycin and MDR-TB, respectively. Adjusted odds ratios (95% confidence interval) of MDR-TB were 5.4 (2.68-11.03), and 4.2 (2.10, 8.45) for retreatment patients, and on treatment patients, respectively. 

Conclusions: drug resistance tuberculosis is considerable problem in upper part of southern Thailand. Major risk factors involved previous history of TB treatment. Thus, it emphasizes on patients who had a history of previous TB treatment. 

Author Biographies

Tum Boonrod, Kasetsart University, Bangkok, Thailand Thailand

Department of Statistics, Faculty of Science

Lily Ingsrisawang, Kasetsart University, Bangkok, Thailand Thailand

Department of Statistics, Faculty of Science

Petchawan Pungrassami, Ministry of Public Health, Thailand Thailand

Bureau of Tuberculosis, Department of Disease Control

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Published

2022-02-02

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Section

Original articles