GLP-1 Receptor Agonists and Substance Use Disorders: A Public Health Opportunity with Emerging Safety Concerns

Authors

DOI:

https://doi.org/10.54103/2282-0930/29800

Keywords:

GLP-1 receptor agonists, Substance use disorders, Pharmacovigilance, Psychiatric safety, Public health, Behavioral pharmacotherapy

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Author Biographies

Silvia Martinelli, Università Cattolica del Sacro Cuore

Department of Life Sciences and Public Health

Niccolò Petrucciani, Sapienza University of Rome

Department of Medical and Surgical Sciences and Translational Medicine, Division of General and Hepatobiliary Surgery, St. Andrea Hospital

References

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Lee S, Li M, Le GH, Teopiz KM, Vinberg M, Ho R, et al. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) as treatment for nicotine cessation in psychiatric populations: a systematic review. Ann Gen Psychiatry. 2024 Nov 11;23(1):45.

Qeadan F, McCunn A, Tingey B. The association between glucose-dependent insulinotropic polypeptide and/or glucagon-like peptide-1 receptor agonist prescriptions and substance-related outcomes in patients with opioid and alcohol use disorders: A real-world data analysis. Addiction. 2024 Oct 16;

Kornelius E, Huang JY, Lo SC, Huang CN, Yang YS. The risk of depression, anxiety, and suicidal behavior in patients with obesity on glucagon like peptide-1 receptor agonist therapy. Sci Rep. 2024 Oct 18;14(1):24433.

Martinelli S, Mazzotta A, Longaroni M, Petrucciani N. Potential role of glucagon-like peptide-1 (GLP-1) receptor agonists in substance use disorder: A systematic review of randomized trials. Drug Alcohol Depend. 2024 Nov 1;264:112424.

du Soulier N, Pariente A, Bezin J, Grenet G, Faillie JL, de Germay S. Use and Potential Misuse of Glucagon-Like Peptide-1 Receptor Agonists in France: A Nationwide Cohort Study. Value Health. 2025 Jun 23:S1098-3015(25)02404-0.

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Published

2025-11-25

How to Cite

1.
Martinelli S, Petrucciani N. GLP-1 Receptor Agonists and Substance Use Disorders: A Public Health Opportunity with Emerging Safety Concerns. ebph [Internet]. 2026 [cited 2026 Feb. 4];21(1). Available from: https://riviste.unimi.it/index.php/ebph/article/view/29800
Received 2025-09-11
Accepted 2025-10-25
Published 2025-11-25