Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement

Authors

  • A. Cecile J.W. Janssens Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
  • John P.A. Ioannidis Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece - Biomedical Research Institute, Foundation for Research and Technology, Ioannina, Greece - Department of Medicine, Tufts University School of Medicine, Boston MA, USA - Center for Genetic Epidemiology and Modeling and Tufts CTSI, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston MA, USA - Department of Epidemiology, Harvard School of Public Health, Boston MA, USA
  • Cornelia M. van Duijn Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
  • Julian Little Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa ON, Canada
  • Muin J. Khoury Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta GA, USA

DOI:

https://doi.org/10.2427/6347

Keywords:

Genetic risk models, GRIPS

Abstract

The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but the quality and completeness of reporting varies.A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines.These recommendations aim to enhance the transparency of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis.
A detailed Explanation and Elaboration document is published separately in PLoS Medicine as Supporting Information (S1) and in Janssens AC, Ioannidis JP, van Duijn CM, Little J, Khoury MJ; GRIPS Group. Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. Eur J Epidemiol 2011; 26(4): 255-9....

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Published

2024-03-19

Issue

Vol. 9 No. 2 (2012)

Section

Articles