N-Acetyltransferase 2 status and gastric cancer risk: a preliminary meta-analysis

Authors

  • Stefania Boccia Institute of Hygiene, Catholic University Medical Scholo, Rome, Italy
  • Giuseppe La Torre Institute of Hygiene, Catholic University Medical Scholo, Rome, Italy
  • Francesco Gianfagna Institute of Hygiene, Catholic University Medical Scholo, Rome, Italy
  • Gualtiero Ricciardi Institute of Hygiene, Catholic University Medical Scholo, Rome, Italy

DOI:

https://doi.org/10.2427/5998

Keywords:

gastric cancer, genetic epidemiology, N- Acetyltransferase 2, meta-analysis

Abstract

In recent studies N- Acetyltransferase 2 (NAT2) genotype has been considered as a risk factor for developing
gastric cancer, however with conflicting results among Asian and Caucasian populations. In order to clarify
the influence of NAT2 slow acetylation status on gastric cancer risk, a preliminary meta-analysis of published
case-control studies was undertaken. The primary outcome measure was the odds ratio (OR) for the risk of
gastric cancer associated with the NAT2 slow genotype using a random effects model. Pooling the results
from the 5 studies identified (771 cases, 1083 controls), an overall OR for gastric cancer risk associated with
the NAT2 slow genotype of 0.91 emerged (95% CI: 0.54-1.55). The result suggests that the NAT2 slow
genotype has probably no effect on the risk of gastric cancer. Additional epidemiological studies, based on
sample sizes that are commensurate with the detection of small genotypic risks, are required to confirm
these findings. Future studies may also help to clarify whether geographic differences exist.

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Published

2005-03-31

Issue

Vol. 2 No. 1 (2005)

Section

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