Il desiderio e l'ossessione del desiderio
DOI:
https://doi.org/10.13130/2240-9599/4191Abstract
Desire is characterized by fluctuations in quality and quantity in most people, but sometimes these changes may result in a psychiatric condition. The spectrum of possible alterations is wide, and it may be characterized by very different clinical pictures.
The main role of the neurobiological mechanisms that underlie desire is played by dopamine, a neurotransmitter whose concentration can be modified by use or abuse of several compounds, which may have a therapeutic role, in the case of medicines, or may lead to dysfunctional situations, in the case of substances or alcohol.
Neuroimaging studies have allowed a better knowledge of brain areas involved in mental illnesses, recording functional changes during the execution of specific tasks. The improvement of these techniques in the near future will improve the choice of the most appropriate treatment for each disease, leading to patient tailored therapies.
Different approaches to the treatment of disorders associated with an alteration of desire are currently available; often their combination, such as the one between psychophamacological drugs and psychotherapy, can lead to a better therapeutic result and to a reduction, or mitigation, of episodes’ of severity and recurrences.
Riferimenti bibliografici
ALTAMURA, Alfredo Carlo, Bipolar spectrum and drug addiction, «Journal of Affective Disorders» 99 (2007), 1-3, p. 285.
ALTAMURA, Alfredo Carlo, Fondamenti di psichiatria e psicofarmacologia clinica, Roma, Il Pensiero Scientifico Editore, 2009.
ALTAMURA, Alfredo Carlo – ARMADOROS, D. - JAEGER, Marianne – KERNISH, R. – LOCKLEAR, J. – VOLZ, Hans Peter, Importance of open access to atypical antipsychotics for the treatment of schizophrenia and bipolar disorder: a European perspective, «Current Medical Research and Opinion» 24 (2008) 8, pp. 2271-2282.
ALTAMURA, Alfredo Carlo - BOBO, William V. - MELTZER, Herbert Y., Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment, «International Clinical Psychopharmacology» 22 (2007) 5, pp. 249-267.
ALTAMURA, Alfredo Carlo - DELL’OSSO, Bernardo - BUOLI, Massimiliano - BOSI, Monica - MUNDO, Emanuela, Short-term intravenous citalopram augmentation in partial/nonresponders with major depression: a randomized placebo-controlled study, «International Clinical Psychopharmacology» 23 (2008), 4, pp. 198-202.
ALTAMURA, Alfredo Carlo - GOIKOLEA, Jose Manuel, Differential diagnoses and management strategies in patients with schizophrenia and bipolar disorder, «Neuropsychiatric Disease and Treatment» 4 (2008), 1, pp. 311-317.
ALTAMURA, Alfredo Carlo - MUNDO, Emanuela - DELL’OSSO, Bernardo, TACCHINI, Gianluigi - BUOLI, Massimiliano - CALABRESE, Joseph, Quetiapine and classical mood stabilizers in the long-term treatment of bipolar disorder: a 4-year follow-up naturalistic study, «Journal of Affective Disorders» 110 (2008), 1-2, pp. 135-141.
ALTAMURA, Alfredo Carlo - SANTINI, Annalisa - MUNDO, Emanuela, Treatment issues in bipolar II depression. «The International Journal of Neuropsychopharmacology» 9 (2006), 6, pp. 775-776.
AMERICAN PSYCHIATRIC ASSOCIATION, DSM-IV-TR. Manuale diagnostico e statistico dei disturbi mentali. Text revision, Milano, Masson Editore, 2007.
CARPENTER, William T. - KOENIG, James I., The evolution of drug development in schizophrenia: past issues and future opportunities, «Neuropsychopharmacology» 33 (2008), 9, pp. 2061-2079.
CARPENTER, William T.., Schizophrenia: disease, syndrome, or dimensions? «Fam Process» 46 (2007), 2, pp. 199-206.
CARTER, R. McKell - MACINNES, Jeff – HUETTEL, Scott A. - ADCOCK, R. Alison, Activation in the VTA and Nucleus Accumbens. Increases in anticipation of both gains and losses, «Frontiers in Behavioral Neuroscience» 3 (2009).
CHAMBERLAIN, Samuel R. - ODLAUG, Brian L. - BOULOUGOURIS, Vasileios - FINEBERG, Naomi A. – GRANT, Jon E., Trichotillomania: neurobiology and treatment, «Neuroscience and Biobehavioral Reviews» 33 (2009), 6, pp. 831-842.
CODISPOTI, Maurizio - GERRA, Gilberto - MONTEBAROCCI, Ornella - ZAIMOVIC, Amir - RAGGI, Maria Augusta - BALDARO, Bruno, Emotional perception and neuroendocrine changes, «Psychophysiology» 40 (2003), 6, pp. 863-868.
DELL’OSSO, Bernardo - ALLEN, Andrea - HOLLANDER, Eric, Comorbidity issues in the pharmacological treatment of pathological gambling: a critical review, «Clinical Practice and Epidemiology in Mental Health» 10 (2005), pp. 1-21.
DELL’OSSO, Bernardo - ALLEN, Andrea - ALTAMURA, Alfredo Carlo - BUOLI, Massimiliano - HOLLANDER, Eric, Impulsive-compulsive buying disorder: clinical overview, «Australian and New Zealand Journal of Psychiatry» 42 (2008), 4, pp. 259-266.
DELL’OSSO, Bernardo - ALTAMURA, Alfredo Carlo - ALLEN, Andrea - MARAZZITI, Donatella - HOLLANDER, Eric, Epidemiologic and clinical updates on impulse control disorders: a critical review, «European Archives of Psychiatry and Clinical Neuroscience» 256 (2006), 8, pp. 464-475.
DELL’OSSO, Bernardo - ALTAMURA, Alfredo Carlo - MUNDO, Emanuela - MARAZZITI, Donatella - HOLLANDER, Eric, Diagnosis and treatment of obsessive-compulsive disorder and related disorders, «International Journal of Clinical Practice» 61 (2007), 1, pp. 98-104.
DELL’OSSO, Bernardo - MUNDO, Emanuela - MARAZZITI, Donatella - ALTAMURA, Alfredo Carlo, Switching from serotonin reuptake inhibitors to duloxetine in patients with resistant obsessive compulsive disorder: a case series, «Journal of Psychopharmacology» 22 (2008), 2, pp. 210-213.
DI CHIARA, Gaetano - BASSAREO, Valentina, Reward system and addiction: what dopamine does and doesn’t do, «Current Opinion in Pharmacology» 7 (2007), 1, pp. 69-76.
FINEBERG, Naomi A. - CRAIG, Kathrine J., Pharmacological treatment of obsessive-compulsive disorders, «Journal of Psychopharmacology» (2008, ahead of print).
GERRA, Gilberto - BERTACCA, Simone - ZAIMOVIC, Amir - PIRANI, M. - BRANCHI, Barbara - FERRI, Marica, Relationship of personality traits and drug of choice by cocaine addicts and heroin addicts, «Substance Use Misuse» 43 (2008), 3-4, pp. 317-330.
GRANT Jon E. - ODLAUG, Brian L., Update on pathological skin picking, «Current Psychiatry Reports» 11 (2009), 4, pp. 283-288.
GRANT, Jon E. - KIM Suck Won - ODLAUG, Brian L., A double-blind, placebo-controlled study of the opiate antagonist, naltrexone, in the treatment of kleptomania, «Biological Psychiatry» 65 (2009), 7, pp. 600-606.
IPSER, Jonathan C. - SANDER, Candice - STEIN, Dan J., Pharmacotherapy and psychotherapy for body dysmorphic disorder, «Cochrane Database of Systematic Reviews» 1 (2009).
KANE John M. - LENCZ, Todd, Cognitive deficits in schizophrenia: short-term and long-term, «World Psychiatry» 7 (2008), 1, pp. 29-30.
KANE John M., An evidence-based strategy for remission in schizophrenia, «Journal of Clinical Psychiatry» 69 (2008), 3, pp. 25-30.
KIM Suck Won - GRANT, Jon E. - POTENZA, Marc N. - BLANCO, Carlos - HOLLANDER, Eric, The gambling symptom assessment scale (G-SAS): a reliability and validity study, «Psychiatry Research» 166 (2009), 1, pp. 76-84.
KRONMÜLLER, Klaus-Thomas - SCHRÖDER, Johannes - KÖHLER, Sebastian - GÖTZ, Bianca - VICTOR, Daniela - UNGER, Jörg - GIESEL, Frederic - MAGNOTTA, Vincent - MUNDT, Christoph - ESSIG, Marco - PANTEL, Joannes, Hippocampal volume in first episode and recurrent depression, «Psychiatry Res» 174 (2009), 1, pp. 62-66.
MAHON, Katie - BURDICK, Katherine E. - SZESZKO, Philip R., A role for white matter abnormalities in the pathophysiology of bipolar disorder, «Neuroscience & Biobehavioral Reviews» (2009, ahead of print).
MARAZZITI, Donatella - GIANNOTTI, Daniele - CATENA, Mario - CARLINI, Marina – DELL’OSSO, Bernardo - PRESTA, Silvio - PFANNER, Chiara - MUNGAI, Francesco – DELL’OSSO, Liliana, Insight in body dysmorphic disorder with and without comorbid obsessive-compulsive disorder, «CNS Spectrums» 11 (2006), 7, pp. 494-498.
MARTINEZ, Diana - GREENE, Kaitlin - BROFT, Allegra - KUMAR, Dileep – LIU, Fei - NARENDRAN, Rajesh - SLIFSTEIN, Mark - VAN HEERTUM, Ronald - KLEBER, Herbert D., Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion, «The American Journal of Psychiatry» 166 (2009), 10, pp. 1170-1177.
MUNDO, Emanuela - ZANONI, S. - ALTAMURA, Alfredo Carlo, Genetic issues in obsessive-compulsive disorder and related disorders, «Psychiatric Annals» 36 (2006), 7, pp. 493-512.
PETROVIC, Predrag - PLEGER, Burkhard - SEYMOUR, Ben - KLÖPPEL, Stefan - DE MARTINO, Benedetto - CRITCHLEY, Hugo - DOLAN, Raymond J., Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses, «The Journal of Neuroscience» 28 (2008), 42, pp. 10509-10516.
PHILLIPS, Katharine A. - HOLLANDER, Eric, Treating body dysmorphic disorder with medication: evidence, misconceptions, and a suggested approach, «Body Image» 5 (2008), 1, pp. 13-27.
POTENZA, Marc N., Non-substance and substance addictions, «Addiction» 104 (2009), 6, pp. 1016-1017.
POTENZA, Marc N., Review. The neurobiology of pathological gambling and drug addiction: an overview and new findings, «Philosophical Transactions of the Royal Society of Biological Sciences» 363 (2008), 1507, pp. 3181-3189.
STEIN, Dan J. - DENYS, Damiaan - GLOSTER, Andrew T. - HOLLANDER, Eric - LECKMAN, James F. - RAUCH, Scott L. - PHILLIPS, Katharine A., Obsessive-compulsive disorder: diagnostic and treatment issues, «Psychiatric Clinics of North America» 32 (2009), 3, pp. 665-685.
VERHEIJ Michel M.M. - COOLS, Alexander R., Twenty years of dopamine research: individual differences in the response of accumbal dopamine to environmental and pharmacological challenges, «European Journal of Pharmacoly» 584 (2008), 2-3, pp. 228-244.
WHITESIDE, Stephen P. - PORT, John D. - ABRAMOWITZ, Jonathan S., A meta-analysis of functional neuroimaging in obsessive-compulsive disorder «Psychiatry Res» 132 (2004), 1, pp. 69-79.
YOON, Jong H. - MINZENBERG, Michael J. - URSU, Stefan - RYAN, Walter - WENDELKEN, Carter - RAGLAND, J. Daniel - CARTER, Cameron S., Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global function, «The American Journal of Psychiatry» 165 (2008), 8, pp. 1006-1014.
ZOHAR, Joseph, Escitalopram in the treatment of obsessive-compulsive disorder, «Expert Review of Neurotherapeutics» 8 (2008), 3, pp. 339-349.
