Therapeutic adherence among adolescents with HIV. A literature review

Authors

  • Laura Bucci Polyclinic, Centro Diagnostico Italiano, Milan, Italy
  • Ernesto Evicelli Bachelor School of Nursing, ASST Fatebenefratelli-Sacco, "Sacco" Campus, Milan, Italy https://orcid.org/0009-0002-7055-583X
  • Alessia Sorrenti Bachelor School of Nursing, Don Gnocchi Foundation, Milan, Italy https://orcid.org/0009-0008-6899-1572
  • Jesus Francisco Javier Leon Garcia Bachelor School of Nursing, Don Gnocchi Foundation, Milan, Italy https://orcid.org/0009-0004-0276-6859

DOI:

https://doi.org/10.54103/dn/22736

Keywords:

HIV, Education, Intervention, therapeutic adherence, quality of life, Adolescents

Abstract

BACKGROUND: According to World Health Organization, in 2022 approximately 1.5 million people under the age of 15 are affected by HIV. The adolescent population has a higher risk of not effectively adhering to antiretroviral therapy.

AIM: To identify interventions to improve therapeutic adherence to antiretroviral therapy (ART) in adolescents with HIV.

METHODS: A narrative literature review was conducted from March to July 2023. Primary studies with populations aged 13-17 years were included. Articles were obtained from PubMed, PsycInfo, Embase, and CINAHL databases through specific query strings.

RESULTS: Ten articles were included, 4 of which were conducted in America and 6 in Africa. Interventions that improve therapeutic adherence were multidimensional and multidisciplinary. They were clustered into 6 macro-areas: knowledge enhancement, revelation of serological status, reduction of social stigma, personal support, improvement of pre-existing therapeutic adherence,  utilization of resources and cultural background and habits. These interventions can be performed by nurses, physicians, psychologists and skilled workers. Facilitators to improve therapeutic adherence include ongoing social support, confidentiality protection and ART education.

CONLUSIONS: The most effective interventions concern enhancing HIV knowledge through health education, revealing sero-status according to the adolescent's understanding and maturity, and using technological tools that facilitate treatment adherence.

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References

World Health Organization. HIV Data and Statistics [Internet]. 2023. Available from: https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/hiv/strategic-information/hiv-data-and-statistics

Crowley T, Rohwer A. Self-management interventions for adolescents living with HIV: a systematic review. BMC Infect Dis. 2021 May;21(1):431. DOI: https://doi.org/10.1186/s12879-021-06072-0

Orofino G, Guastavigna M. Aderenza alla terapia antiretrovirale negli adolescenti con infezione da HIV: una questione aperta per il team multidisciplinare. JHA - J HIV Ageing. 2018;(4):87–91. DOI: https://doi.org/10.19198/JHA31460

Musayón-Oblitas Y, Cárcamo C, Gimbel S. Counseling for improving adherence to antiretroviral treatment: a systematic review. AIDS Care. 2019 Jan;31(1):4–13. DOI: https://doi.org/10.1080/09540121.2018.1533224

Kim S-H, Gerver SM, Fidler S, Ward H. Adherence to antiretroviral therapy in adolescents living with HIV: systematic review and meta-analysis. AIDS. 2014 Aug;28(13):1945–56. DOI: https://doi.org/10.1097/QAD.0000000000000316

Wasti SP, Simkhada P, Randall J, Freeman J V, van Teijlingen E. Factors influencing adherence to antiretroviral treatment in Nepal: a mixed-methods study. PLoS One. 2012;7(5):e35547. DOI: https://doi.org/10.1371/journal.pone.0035547

Juárez O, Díez E. AIDS prevention among adolescents in school: a systematic review of the efficacy of interventions. Gac Sanit [Internet]. 1999;13(2):150–62. Available from: http://dx.doi.org/10.1016/S0213-9111(99)71340-3 DOI: https://doi.org/10.1016/S0213-9111(99)71340-3

Graves JC, Elyanu P, Schellack CJ, Asire B, Prust ML, Prescott MR, et al. Impact of a Family Clinic Day intervention on paediatric and adolescent appointment adherence and retention in antiretroviral therapy: A cluster randomized controlled trial in Uganda. PLoS One. 2018;13(3):e0192068. DOI: https://doi.org/10.1371/journal.pone.0192068

Wiggins L, O’Malley G, Wagner AD, Mutisya I, Wilson KS, Lawrence S, et al. “They can stigmatize you”: a qualitative assessment of the influence of school factors on engagement in care and medication adherence among adolescents with HIV in Western Kenya. Health Educ Res. 2022;37(5):355–63. DOI: https://doi.org/10.1093/her/cyac018

Okonji EF, Wyk B Van, Hughes GD, Mukumbang FC. Implementation of a Psychosocial Support Intervention for Adolescents on Antiretroviral Treatment: Challenges and Experiences from Ehlanzeni District, South Africa. J Int Assoc Provid AIDS Care. 2022;21:23259582221121096. DOI: https://doi.org/10.1177/23259582221121094

Navarra A-MD, Ford H, Cleland CM, Liang E, Rodriguez, Neu NK. Engaging and Supporting Youth to Promote Adherence Success (EASYPAS): A Cognitive Behavioral Intervention for Youth Living With HIV. J Assoc Nurses AIDS Care. 2019;30(3):372–8. DOI: https://doi.org/10.1097/JNC.0000000000000034

Olashore AA, Paruk S, Ogunwale A, Ita M, Tomita A, Chiliza B. The effectiveness of psychoeducation and problem-solving on depression and treatment adherence in adolescents living with HIV in Botswana: an exploratory clinical trial. Child Adolesc Psychiatry Ment Health [Internet]. 2023;17(1):1–10. Available from: https://doi.org/10.1186/s13034-022-00541-3 DOI: https://doi.org/10.1186/s13034-022-00541-3

Hosek SG, Harper GW, Lemos D, Burke-Miller J, Lee S, Friedman L, et al. Project ACCEPT: Evaluation of a Group-Based Intervention to Improve Engagement in Care for Youth Newly Diagnosed with HIV. AIDS Behav. 2018 Aug;22(8):2650–61. DOI: https://doi.org/10.1007/s10461-018-2034-4

Crowley T, van der Merwe A, Kidd M, Skinner D. Adolescent human immunodeficiency virus self-management: Associations with treatment adherence, viral suppression, sexual risk behaviours and health-related quality of life. South Afr J HIV Med. 2020;21(1):1054. DOI: https://doi.org/10.4102/sajhivmed.v21i1.1054

Abiodun O, Ladi-Akinyemi B, Olu-Abiodun O, Sotunsa J, Bamidele F, Adepoju A, et al. A Single-Blind, Parallel Design RCT to Assess the Effectiveness of SMS Reminders in Improving ART Adherence Among Adolescents Living with HIV (STARTA Trial). J Adolesc Heal Off Publ Soc Adolesc Med. 2021 Apr;68(4):728–36. DOI: https://doi.org/10.1016/j.jadohealth.2020.11.016

Navarra A-MD, Rosenberg MG, Gormley M, Bakken S, Fletcher J, Whittemore R, et al. Feasibility and Acceptability of the Adherence Connection Counseling, Education, and Support (ACCESS) Proof of Concept: A Peer-Led, Mobile Health (mHealth) Cognitive Behavioral Antiretroviral Therapy (ART) Adherence Intervention for HIV-Infected (HIV+) Adolescents and Young Adults (AYA). AIDS Behav. 2023 Jun;27(6):1807–23. DOI: https://doi.org/10.1007/s10461-022-03913-0

Amico KR, Lindsey JC, Hudgens M, Dallas R, Horvath KJ, Dunlap A, et al. Randomized Controlled Trial of a Remote Coaching mHealth Adherence Intervention in Youth Living with HIV. AIDS Behav. 2022 Dec;26(12):3897–913. DOI: https://doi.org/10.1007/s10461-022-03717-2

Hlophe LD, Tamuzi JL, Shumba CS, Nyasulu PS. Barriers and facilitators to anti-retroviral therapy adherence among adolescents aged 10 to 19 years living with HIV in sub-Saharan Africa: A mixed-methods systematic review and meta-analysis. PLoS One. 2023;18(5):e0276411. DOI: https://doi.org/10.1371/journal.pone.0276411

Published

2024-07-31

How to Cite

Bucci, L., Evicelli, E., Sorrenti, A., & Leon Garcia, J. F. J. (2024). Therapeutic adherence among adolescents with HIV. A literature review. Dissertation Nursing, 3(2), 145–168. https://doi.org/10.54103/dn/22736
Received 2024-03-18
Accepted 2024-06-13
Published 2024-07-31